Editorial: NETosis 2: The Excitement Continues
نویسندگان
چکیده
1Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany, 2 Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, United States, 3 Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, United States
منابع مشابه
Extracellular Chromatin Traps Interconnect Cell Biology, Microbiology, and Immunology
because the reaction pathway of this enzyme is understood in molecular detail. Leshner et al. (2012) provide an elegant illustration of PAD4’s potential to induce NETs. They demonstrate that overexpression of PAD4 in heterologous cells leads to chromatin decondensation and unfolding of NET-like chromatin. Induced PAD4 expression leads to histone deimination and the release of NET-like webs from...
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Neutrophils are short-lived innate immune cells. These cells respond quickly to stimuli, and die within minutes to hours; the relevance of DNA transcription in dying neutrophils remains an enigma for several decades. Here we show that the transcriptional activity reflects the degree of DNA decondensation occurring in both NADPH oxidase 2 (Nox)-dependent and Nox-independent neutrophil extracellu...
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